Autonomic symptoms following Zika virus infection

Yhojan Rodríguez; Manuel Rojas; Carolina Ramírez-Santana; Yeny Acosta-Ampudia; Diana M. Monsalve; Juan Manuel Anaya

doi:10.1007/s10286-018-0515-1

Autonomic symptoms following Zika virus infection

Yhojan Rodríguez, Manuel Rojas, Carolina Ramírez-Santana, Yeny Acosta-Ampudia, Diana M. Monsalve, Juan Manuel Anaya

School of Medicine and Health Sciences

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

Abstract

Purpose: To determine if autonomic symptoms are associated with previous Zika virus infection. Methods: Case–control study including 35 patients with Zika virus infection without evidence of neurological disease and 105 controls. Symptoms of autonomic dysfunction were assessed with the composite autonomic symptom scale 31 (COMPASS-31). Results: Patients with previous Zika virus infection had significantly higher COMPASS-31 score than controls regardless of age and sex (p = 0.007). The main drivers for the higher scores where orthostatic intolerance (p = 0.003), secretomotor (p = 0.04) and bladder symptoms (p < 0.001). Conclusion: Zika virus infection is associated with autonomic dysfunction. The mechanisms remain to be elucidated.

Original language	English
Pages (from-to)	211-214
Number of pages	4
Journal	Clinical Autonomic Research
Volume	28
Issue number	2
DOIs	https://doi.org/10.1007/s10286-018-0515-1
Publication status	Published - Apr 1 2018

Bibliographical note

Publisher Copyright:
© 2018, Springer-Verlag GmbH Germany, part of Springer Nature.

ASJC Scopus Subject Areas

Endocrine and Autonomic Systems
Clinical Neurology

Keywords

Autonomic symptoms
COMPASS 31
Dysautonomia
Flavivirus
Zika virus

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10.1007/s10286-018-0515-1

Cite this

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abstract = "Purpose: To determine if autonomic symptoms are associated with previous Zika virus infection. Methods: Case–control study including 35 patients with Zika virus infection without evidence of neurological disease and 105 controls. Symptoms of autonomic dysfunction were assessed with the composite autonomic symptom scale 31 (COMPASS-31). Results: Patients with previous Zika virus infection had significantly higher COMPASS-31 score than controls regardless of age and sex (p = 0.007). The main drivers for the higher scores where orthostatic intolerance (p = 0.003), secretomotor (p = 0.04) and bladder symptoms (p < 0.001). Conclusion: Zika virus infection is associated with autonomic dysfunction. The mechanisms remain to be elucidated.",

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AU - Rodríguez, Yhojan

AU - Rojas, Manuel

AU - Ramírez-Santana, Carolina

AU - Acosta-Ampudia, Yeny

AU - Monsalve, Diana M.

AU - Anaya, Juan Manuel

PY - 2018/4/1

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N2 - Purpose: To determine if autonomic symptoms are associated with previous Zika virus infection. Methods: Case–control study including 35 patients with Zika virus infection without evidence of neurological disease and 105 controls. Symptoms of autonomic dysfunction were assessed with the composite autonomic symptom scale 31 (COMPASS-31). Results: Patients with previous Zika virus infection had significantly higher COMPASS-31 score than controls regardless of age and sex (p = 0.007). The main drivers for the higher scores where orthostatic intolerance (p = 0.003), secretomotor (p = 0.04) and bladder symptoms (p < 0.001). Conclusion: Zika virus infection is associated with autonomic dysfunction. The mechanisms remain to be elucidated.

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Autonomic symptoms following Zika virus infection

Abstract

Bibliographical note

ASJC Scopus Subject Areas

Keywords

Access to Document

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